CAR T-Cell Therapy for Revolutionizing Cancer Treatment | Max Hospital

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What Is CAR T-Cell Therapy: Challenges & Advancements in Cancer Treatment

By Dr. Nivedita Dhingra in Medical Oncology , Cancer Care / Oncology

Dec 07 , 2023 | 1 min read

Traditionally, treatment for blood cancers, like chemotherapy and bone marrow transplants, has been the mainstay. However, for some patients, these therapies fail to provide lasting results. This is where CAR T-cell therapy emerges as a game-changer.

CAR T-cell therapy, also known as Chimeric Antigen Receptor T-cell therapy, represents a revolutionary approach to cancer immunotherapy. It involves harnessing a patient's own immune system to fight cancer. Here's how it works:

T-Cells and Genetic Modification: T-cells are vital components of our immune system and are extracted from the patient through a process called apheresis. These T-cells are genetically modified in a laboratory to express a chimeric antigen receptor (CAR).
Targeting Cancer Cells: The CAR on these modified T-cells enables them to specifically recognize and bind to proteins on cancer cells, which are otherwise difficult for the immune system to detect.
Treatment Process: After genetic modification, the CAR T-cells are cultured and multiplied over a few weeks. During this time, patients may undergo low-dose chemotherapy to control cancer and prepare their body for CAR T-cell infusion.
Infusion and Monitoring: Once ready, the CAR T-cells are infused back into the patient, similar to a blood transfusion. Post-infusion, patients are closely monitored for potential side effects, such as fever or neurological issues, requiring hospitalization for up to two weeks.

Success and Challenges of CAR T-Cell Therapy

CAR T-cell therapy has shown success in treating relapsed or refractory B-cell malignancies, like acute lymphoblastic leukaemia and certain types of lymphoma. Patients who have exhausted conservative treatment options now have renewed hope with CAR T-cell therapy.

CAR T-Cell Therapy Advancements in India

While initially developed and widely used in Western countries, CAR T-cell therapy has become more accessible in India with the advent of indigenous products like Next Car 19, developed by IIT Mumbai. This development not only brings hope to patients but also makes treatment more affordable and accessible.

In conclusion, CAR T-cell therapy represents a significant leap forward in treating blood cancers, offering a personalized and potent treatment option where traditional therapies fall short. As we advance in medical research and technology, the future looks promising for patients who once faced limited treatment options.

If you or someone you know could benefit from CAR T-cell therapy, I encourage you to seek further consultation to explore this innovative treatment.